Publications

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• MacCalman A, De Franco E, Franklin A, Flaxman CS, Richardson SJ, Murrall K,Burrage J , Barts Pancreas Tissue Bank (BPTB), Walker WM, Morgan NG, Hattersley AT, Dempster EL, Hannon E, Jeffries AR, Owens NDL, Mill J. BMC Genomics 25, 553 (2024).
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• Laver TW, Wakeling MN, Caswell RC, Bunce B, Yau D, Houghton JAL, Hopkins JJ, Weedon MN, Saraff V, Kershaw M, Honey EM, Murphy N, Giri D, Nath S, Saredo AT, Banerjee I, Hussain K, Owens NDL, Flanagan SE. (2023). Chromosome 20p11.2 deletions cause congenital hyperinsulinism via the likely disruption of FOXA2. European Journal of Human Genetics (2024).
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• De Franco, Owens NDL, Montaser H*, Wakeling MN, Saarimäki-Vire J, Ibrahim H, et al. Primate-specific ZNF808 is essential for pancreatic development in humans. Nature Genetics. 2023
  DOI | Data and Code

• Stankovic S, Shekari S, Huang QQ, Gardner EJ, Owens ND*, Azad A, Hawkes G, Kentistou KA, Beaumont RN, Day FR, Zhao YN. Genetic susceptibility to earlier ovarian ageing increases de novo mutation rate in offspring. medRxiv; 2022
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• Sempou E, Kostiuk V, Zhu J, Guerra C, Tyan L, Hwang W, Aguilar EC, Caplan MJ, Zenisek D, Warmflash A, Owens NDL, Khokha MK. Membrane potential drives the exit from pluripotency and the ontogeny of cell fate via calcium and mTOR. Nature Communications. 13,1 6681. 2022
  DOI | PubMed | Data and Code

• Wakeling MN, Owens NDL, Hopkinson JR, Johnson MB, Houghton JAL, Dastamani A, et al. A novel disease mechanism leading to the expression of a disallowed gene in the pancreatic beta-cell identified by non-coding, regulatory mutations controlling HK1. Nature Genetics. 54,11 2022.
  DOI | PubMed | Data and Code